Brief Communications High-Frequency Hippocampal Oscillations Activated by Optogenetic Stimulation of Transplanted Human ESC-Derived Neurons
نویسندگان
چکیده
Juan C. Piña-Crespo,1* Maria Talantova,1* Eun-Gyung Cho,1* Walid Soussou,1 Nima Dolatabadi,1 Scott D. Ryan,1 Rajesh Ambasudhan,1 Scott McKercher,1 Karl Deisseroth,2 and Stuart A. Lipton1 1Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, and 2Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305
منابع مشابه
High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons.
After transplantation, individual stem cell-derived neurons can functionally integrate into the host CNS; however, evidence that neurons derived from transplanted human embryonic stem cells (hESCs) can drive endogenous neuronal network activity in CNS tissue is still lacking. Here, using multielectrode array recordings, we report activation of high-frequency oscillations in the β and γ ranges (...
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